The new 15th district stretches from Hidalgo County in the Rio Grande Valley(including Edinburg and Weslaco), and now extends northeasterly into several rural counties between Corpus Christi, San Antonio and Victoria, including such communities as Falfurrias, Alice, Sinton, Beeville, Cuero and Gonzales. The incumbent is Republican Monica De La Cruz, who was re-elected with 57.1% of the vote in 2024.[18]

In 2024 Donald Trump won with 58.5% in this district.